Hierarchical Structure of Protein Sequence

Most non-communicable diseases are associated with dysfunction of proteins or protein complexes. The relationship between sequence and structure has been analyzed for a long time, the analysis sequences organization in domains motifs remains an actual research area. Here, we propose mathematical method revealing hierarchical sequences. is based on pentapeptide as unit Employing frequency occurrence pentapeptides natural special approach, this revealed sequence. was applied to 24,647 non-homologous sizes ranging from 50 400 residues NRDB90 database. Statistical branching points graphs 11 characteristic values y (the width inscribed function), showing these multiple fragments Several examples illustrate how spatial correspond elements This methodology provides promising basis mathematically-based classification proteins. Elements different levels hierarchy can be used solve biotechnological medical problems.